Synthesis of Simple 3,4-Diarylpyrrole-2,5-dicarboxylic Acids and Lukianol A by Oxidative Condensation of 3-Arylpyruvic Acids with Ammonia

Abstract

Several derivatives of 3,4-diaryl- and 3,4-diindolylpyrrole-2,5-dicarboxylic acids including lycogalic acid A and two Halomonas­ metabolites were synthesized by oxidative dimerization of arylpyruvic acids or arylpyruvates in the presence of ammonia. The reaction can be applied for a short synthesis of lukianol A.

biomimetic synthesis - pyrroles - lycogalic acid - 3,4-diarylpyrrole-2,5-dicarboxylic acids

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