Endoscopy 2007; 39(9): 779-783
DOI: 10.1055/s-2007-966761
Original article

© Georg Thieme Verlag KG Stuttgart · New York

Clinical outcome after endoscopic mucosal resection for esophageal squamous cell carcinoma invading the muscularis mucosae - a multicenter retrospective cohort study

C.  Katada1 , M.  Muto1 , K.  Momma2 , M.  Arima3 , H.  Tajiri4 , C.  Kanamaru4 , H.  Ooyanagi5 , H.  Endo6 , T.  Michida7 , N.  Hasuike8 , I.  Oda8 , T.  Fujii8 , D.  Saito8
  • 1Division of Digestive Endoscopy and Gastrointestinal Oncology, National Cancer Center Hospital East, Kashiwa, Japan
  • 2Department of Endoscopy, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan
  • 3Department of Gastroenterology, Saitama Cancer Center Hospital, Saitama, Japan
  • 4Department of Endoscopy, The Jikei University School of Medicine, Tokyo, Japan
  • 5Department of Diagnostic Imaging, Division of Endoscopy, Tochigi Cancer Center Hospital, Utsunomiya, Japan
  • 6Department of Internal Medicine, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan
  • 7Department of Gastroenterology, Osaka National Hospital, Osaka, Japan
  • 8Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
Weitere Informationen


submitted 22 May 2007

accepted after revision 13 June 2007

17. August 2007 (online)

Background and study aims: Endoscopic mucosal resection (EMR) is now commonly indicated for esophageal squamous cell carcinoma (ESCC) within the lamina propria mucosa. However, EMR for ESCC that has invaded the muscularis mucosa is controversial because the risk of lymph node metastasis is not negligible. We conducted a multicenter retrospective cohort study to investigate the incidence of lymph node metastasis and survival after EMR for ESCC invading the muscularis mucosa.

Patients and methods: A total of 104 patients with 111 lesions invading the muscularis mucosa, were retrospectively studied at eight institutes. No patients exhibited evidence of metastasis of lymph nodes or distant organs prior to EMR. Overall and cause-specific survival rates were calculated from the date of EMR to the date of death or the most recent follow-up visit. Survival curves were plotted according to the Kaplan-Meier method.

Results: In total, 86 patients (82.7 %) who did not receive further treatment such as chemotherapy, irradiation therapy, chemoradiotherapy, or esophagectomy after EMR were followed up. Only two patients (1.9 %) developed lymph node metastasis after EMR. With a median follow-up period of 43 months (range, 8 - 134 months), overall and cause-specific survival rates at 5 years after EMR were 79.5 % and 95.0 %, respectively.

Conclusions: EMR for ESCC that invades the muscularis mucosa has curative potential as a minimally invasive treatment option.


M. Muto, MD

Division of Digestive Endoscopy and Gastrointestinal Oncology

National Cancer Center Hospital East

6-5-1 Kashiwanoha

Kashiwa 277-8577


Fax: +81-4-71314724

eMail: mmuto@east.ncc.go.jp