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Synthesis of Amphidinolide E
P. Va, W. R. Roush*
The Scripps Research Institute, Florida, Jupiter, USA
24 April 2007 (online)
The cis-tetrahydrofuran ring of amphidinolide A is synthesized using a highly diastereoselective [3+2] annulation reaction. Deft use of Fe(CO)3 as protecting group led to successful esterification of a hindered secondary alcohol. For an alternative synthesis of amphidinolide A, see: E. Lee and co-workers Angew. Chem. Int. Ed. 2006, 45, 8019-8021.