Synfacts 2007(5): 0490-0490  
DOI: 10.1055/s-2007-968419
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag Stuttgart · New York

Synthesis of ‘Large’ Calixarenes

Contributor(s): Timothy M. Swager, Trisha L. Andrew
S. P. Bew*, S. V. Sharma
University of East Anglia, Norwich, UK
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24. April 2007 (online)


A tin-mediated procedure to synthesize calix[8]- and [9]arenes preferentially over the commonly made calix[6]- and [4]arenes is reported: calix[8]- and [9]arene are synthesized in 23% and 55% isolated yield, respectively, whereas smaller calix[n]arenes (n = 4-7) are made in 6.5% total yield.