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Synfacts 2007(5): 0535-0535
DOI: 10.1055/s-2007-968431
DOI: 10.1055/s-2007-968431
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Al-Catalyzed Asymmetric Mukaiyama-Michael Reaction and Indole Friedel-Crafts Alkylation
N. Takenaka, J. P. Abell, H. Yamamoto*
The University of Chicago, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
24. April 2007 (online)
Significance
The use of (TBOx)AlSbF6 as chiral catalyst in the Mukaiyama-Michael reaction and the indole Friedel-Crafts reaction is reported. The reactions proceed with excellent enantioselectivities delivering the desired products in acceptable to excellent yields. Si(OEt)3-protected enol ethers undergo the Mukayiama-Michael reaction at lower temperatures than their TMS-protected analogues. The diastereoselectivities in the reactions of tetrasubstituted enolates can thus be improved.