Synfacts 2007(9): 0951-0951  
DOI: 10.1055/s-2007-968847
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Titanium-Promoted Cross-Coupling of Substituted Olefins and Imines

Contributor(s): Mark Lautens, Praew Thansandote
M. Takahashi, G. C. Micalizio*
Yale University, New Haven, USA
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23. August 2007 (online)


A Ti-mediated regio- and stereo­selective cross-coupling of substituted olefins and imines is reported for achiral and chiral homoallylic alcohols and achiral and chiral imines, providing a convenient route to 1,5-amino alcohols which can cyclize to form piperidines.