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Regio- and Enantioselective Iridium-Catalyzed Allylation of Enamines
D. J. Weix, J. F. Hartwig*
Yale University, New Haven and University of Illinois, Urbana, USA
23 August 2007 (online)
This is a nice report for the indirect allylation of ketones. The authors expertly use enamine chemistry to access high regio- and enantioselectivity. Use of a iridium(cod)-phosphoramidite complex gave the branched product with high selectivity. Interestingly, ZnCl2 was added to trap the liberated isopropanol.