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Synfacts 2007(10): 1083-1083  
DOI: 10.1055/s-2007-968933
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

LiAl(Ot-Bu)(i-Bu)2H - A New Reagent for the Reduction of Esters to Aldehydes

Contributor(s): Paul Knochel, Andrei Gavryushin
M. S. Kim, Y. M. Choi, D. K. An*
Kangwon National University, Chunchon, Republic of Korea
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Publication History

Publication Date:
07 November 2007 (online)

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Significance

Direct reduction of esters to aldehydes is an important synthetic transformation. While several reagents for such a transformation have been developed, they mostly require very low temperatures or are not convenient to prepare. The reagent LDBBA smoothly reduces various esters of aromatic, heteroaromatic, and aliphatic acids into the corresponding aldehydes at 0 °C in high yields. It is very easy to prepare and can be stored at least for half a year.