Biological Active Macrocyclic Diterpenoids from Chinese Drug “Fáng Féng Cáo”; II1. Derivatives of Ovatodiolids and their Cytotoxity2

M. Arisawa; M. Nimura; A. Fujita; T. Hayashi; N. Morita; S. Koshimura

doi:10.1055/s-2007-969157

Planta Medica, Inhaltsverzeichnis

Planta Med 1986; 52(4): 297-299
DOI: 10.1055/s-2007-969157

Full Papers

Biological Active Macrocyclic Diterpenoids from Chinese Drug “Fáng Féng Cáo”; II¹. Derivatives of Ovatodiolids and their Cytotoxity²

M. Arisawa³ , M. Nimura⁴ , A. Fujita³ , T. Hayashi³ , N. Morita³ , S. Koshimura⁵

³Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01, Japan.
⁴Research Institute, Kotobuki Seiyaku Co. Ltd., Sakashiro-machi, Nagano 389-07, Japan.
⁵Department of Experimental Therapeutics, Cancer Research Institute, Kanazawa University, 13-1 Takara-machi, Kanazawa 920.

1 For paper I in this series see Ref. (1).2 Part of this data was presented at The 2nd Annual Meeting of The Medical and Pharmaceutical Society for Wakan-Yaku, Kyoto, September, 1985.

Abstract

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Abstract

Isolated macrocyclic diterpenoids, ovatodiolide (1), 4, 5-epoxyovatodiolide (2), anisomelic acid (3), 4, 7-oxycycloanisomelic acid (4), and 4-methylene-5-oxoanisomelic acid (6), from the Chinese crude drug “Fáng Féng Cáordquo;, and the derivatives of the isolated compounds were tested for their growth inhibiting activities in culture of KB cell line. Besides, the effects of 1 on Ehrlich carcinoma in mice are reported.

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