Inhibition of Lens-Aldose Reductase Activity by Brazilin and Haematoxylin

C. K. Moon; Y. P. Yun; J. H. Lee; H. Wagner; Y. S. Shin

doi:10.1055/s-2007-969397

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Planta Med 1985; 51(1): 66-67
DOI: 10.1055/s-2007-969397

Reports

Inhibition of Lens-Aldose Reductase Activity by Brazilin and Haematoxylin

C. K. Moon¹ , Y. P. Yun¹ , J. H. Lee¹ , H. Wagner² , Y. S. Shin³

¹College of Pharmacy, Seoul National University, San 56-1, Sinlim-Dong, Kwanak-Gu, Seoul 151, Korea
²Institut für Pharmazeutische Biologie, München, Federal Republic of Germany
³Stoffwechsellabor der Universitäts-Kinderklinik der Universität München, München, Federal Republic of Germany

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Publication History

1984

1984

Publication Date:
26 February 2007 (online)

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Abstract

Brazilin and haematoxylin, plant pigments, were examined for their effects on the Bovine-Lens aldose reductase (LAR)-activity. About 50% inhibition was observed in a concentration of 10^-4 M-brazilin and 10^-4 M-haematoxylin, and above 95% inhibition was observed in a concentration of 10^-3 M-brazilin and 10^-3M-haematoxylin. In order to determine the type of inhibition, kinetic studies were also conducted with brazilin and haematoxylin, in which both were found to be noncompetitive inhibitors.

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