Isolation and Hypoglycemic Activity of Aconitans A, B, C and D, Glycans of Aconitum carmichaeli Roots1

Chohachi Konno; Mitsuo Murayama; Kazuhiko Sugiyama; Makoto Arai; Miki Murakami; Michiko Takahashi; Hiroshi Hikino

doi:10.1055/s-2007-969436

Planta Medica, Inhaltsverzeichnis

Planta Med 1985; 51(2): 160-161
DOI: 10.1055/s-2007-969436

Reports

Isolation and Hypoglycemic Activity of Aconitans A, B, C and D, Glycans of Aconitum carmichaeli Roots¹

Chohachi Konno, Mitsuo Murayama, Kazuhiko Sugiyama, Makoto Arai, Miki Murakami, Michiko Takahashi, Hiroshi Hikino

Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan

1 Antidiabetes drugs, Part 5, and Aconitum roots, Part 21. Also Part 82 in the validity of the Oriental medicines

Abstract

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Abstract

An aqueous methanol/water extract of the Oriental crude drug “bushi”, Aconitum carmichaeli roots from Japan, markedly reduced the blood sugar level in mice. Activity-guided fractionation of the extract furnished four glycans, aconitans A, B, C and D. These glycans exhibited prominent hypoglycemic effects in normal and alloxan-produced hyperglycemic mice.

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