Abstract
Liver tyrosine aminotransferase activity is known to be induced by administration
of steroids to adrenalectomized rats. When saikosaponin a, b1, b2, b3, b4, c, d or f was injected intraperitoneally into adrenalectomized rats, no induction
of liver tyrosine aminotransferase activity was observed. Administration of a low
dose of cortisone (6.4 µmol/kg) to adrenalectomized rats also did not induce liver
tyrosine aminotransferase. But this enzyme was induced on administration of this low
dose of cortisone with saikosaponen a (6.4 or 12.8 µmol/kg), d (6.4 or 12.8 µmol/kg)
or f (12.8 µmol/kg). The sturcture-activity relationship of the effects of various
Saikosaponins on the action of cortisone is discuused.
