Isolation and Hypoglycaemic Activity of Panaxans A, B, C, D and E, Glycans of Panax ginseng Roots1

Chohachi Konno; Kazuhiko Sugiyama; Mitsuyo Kano; Michiko Takahashi; Hiroshi Hikino

doi:10.1055/s-2007-969757

Planta Medica, Inhaltsverzeichnis

Planta Med 1984; 50(5): 434-436
DOI: 10.1055/s-2007-969757

Reports

Isolation and Hypoglycaemic Activity of Panaxans A, B, C, D and E, Glycans of Panax ginseng Roots¹

Chohachi Konno, Kazuhiko Sugiyama, Mitsuyo Kano, Michiko Takahashi, Hiroshi Hikino

Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan

1 Antidiabetes drugs, Part 1. Also Part 70 in the series on the validity of the Oriental medicines

Abstract

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Abstract

An aqueous methanol/water extract of the Oriental crude drug “ninjin” (ginseng), Panax ginseng roots from Korea, showed a remarkable hypoglycaemic activity on administration to mice. Fractionation of the extract, along with the pharmacological assays, led to isolation of five glycans, panaxans A, B, C, D and E. These constituents exhibited significant hypoglycaemic actions in normal and alloxan-induced hyperglycaemic mice.

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