Planta Medica, Table of Contents Planta Med 1983; 48(7): 136-141DOI: 10.1055/s-2007-969908 Research Articles © Hippokrates Verlag StuttgartChemistry, 13C-NMR Study and Pharmacology of Two Saponins from Colubrina asiaticaH. Wagner1 , S. Ott[3] 1 , K. Jurcic1 , J. Morton[4] , A. Neszmelyi2 1Institut für Pharmazeutische Biologie der Universität München 2Central Research Institute for Chemistry of the Hungarian Academy of Science, Budapest Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window) Abstract From the leaves of Colubrina asiatica BRONGEN (Rhamnaceae) two saponins have been isolated and structurally elucidated, mainly by 13C-NMR-spectroscopic methods, as jujubogenin-3-O-[2-O-acetyl-3-O-(3-O-β-D-xylopyranosyl-4-O-acetyl-β-D-glucopyranosyl)-α-L-arabinoside] (colubrinoside) and jujubogenin-3-O- [2-O-acetyl -3-O- (2-O- β -D- xylopyranosyl-β-D-glucopyranosyl)-α-L-arabinoside] (colubrin) respectively. Both saponins inhibit the spontaneous motility of mice, even at low doses (1 mg/ kg), they show an antagonistic effect on amphetamine and exert a synergistic activity on chlordiazepoxide. Key Word Index Colubrina asiatica - Rhamnaceae - Dammarane-type Saponins - Jujubogenin - Triglycosides - NMR, Relaxation - Sedative activity PDF (467 kb) References 3 From the thesis S. OTT, Munich 1980. 4 Dr. MORTON (Collectanea, Miami, Coral Gables).
