Planta Medica, Table of Contents Planta Med 1982; 44(2): 100-106DOI: 10.1055/s-2007-971412 Research Articles © Hippokrates Verlag StuttgartDental Caries Prevention by Traditional Chinese Medicines*Part II. Potent Antibacterial Action of Magnoliae Cortex Extracts against Streptococcus MutansT. Namba, M. Tsunezuka, M. Hattori Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan * Part I: Submitted to Shoyakugaku Zasshi Recommend Article Abstract PDF Download(opens in new window) Buy Article(opens in new window) Abstract The ether and methanol extracts of Magnoliae Cortex (barks of Magnolia obovata THUNB. or M. officinalis RHED. et WILS.) had potent antibacterial action against a cariogenic bacterium, Streptococcus matuans. The active principles of the extracts were identified to be magnolol and honokiol, which were bactericidal in the minimal inhibitory concentration (MIC) of 6.3 µg/ml against S. mutans. The antibacterial action of both compounds was stronger than that of berberine, a typical antibacterial alkaloid (MIC: 50 µg/ml), Magnolol and honokiol, however, did not inhibit glucosyltransferase (EC 2.4. 1.5) activity obtained from S. mutans and adherence of the heat-treated cells to glass or smooth tooth surfaces in the presence of glucosyltransferase and sucrose in vitro. Key Word Index Magnolia obovata - Magnolia officinalis - Magnoliaceae - Streptococcus mutans - Magnolol - Honokiol - Dental Caries - Antibacterial Action PDF (508 kb)
