Download PDF
Planta Med 1981; 43(10): 166-174
DOI: 10.1055/s-2007-971494
Research Articles

© Hippokrates Verlag Stuttgart

Antimicrobial Substances in Callus Cultures of Ruta graveolens*

B. Wolters, U. Eilert
  • Institut für Pharmazeutische Biologie der Technischen Universität, Braunschweig
* The work on the acridone alkaloids is part of the projected dissertation of U. EILERT.
Further Information

Publication History

Publication Date:
30 March 2007 (online)

  PDF Download  Permissions and Reprints

Abstract

Callus cultures of Ruta graveolens form at least 17 antimicrobial substances, some of which were identified. It appeared that acridone alkaloids (rutacridone-epoxide, hydroxyrutacridone-epoxide) are the most active substances against bacteria as well as against fungi. In comparison with the medicinally used ethacridine lactate, rutacridone-epoxides proved to be much more active. Coumarins (rutarm, xanthotoxin, bergapten etc.) only cause any inhibition in higher concentrations. Furoquinoline alkaloids (dictamnine, γ-fagarine) are more active than the furocoumarins. Essential oil components and flavonoids do not show any antibiotic activity in our test.

Key Word Index

Ruta graveolens - Rutaceae - Antimicrobial substances - Acridone alkaloid epoxides - Furoquinoline alkaloids - Furocoumarins - Rutarin - Callus culture

      >