Planta Medica, Inhaltsverzeichnis Planta Med 1981; 43(10): 166-174DOI: 10.1055/s-2007-971494 Research Articles © Hippokrates Verlag StuttgartAntimicrobial Substances in Callus Cultures of Ruta graveolens*B. Wolters, U. Eilert Institut für Pharmazeutische Biologie der Technischen Universität, Braunschweig * The work on the acridone alkaloids is part of the projected dissertation of U. EILERT. Artikel empfehlen Abstract als PDF herunterladen(opens in new window) Artikel einzeln kaufen(opens in new window) Abstract Callus cultures of Ruta graveolens form at least 17 antimicrobial substances, some of which were identified. It appeared that acridone alkaloids (rutacridone-epoxide, hydroxyrutacridone-epoxide) are the most active substances against bacteria as well as against fungi. In comparison with the medicinally used ethacridine lactate, rutacridone-epoxides proved to be much more active. Coumarins (rutarm, xanthotoxin, bergapten etc.) only cause any inhibition in higher concentrations. Furoquinoline alkaloids (dictamnine, γ-fagarine) are more active than the furocoumarins. Essential oil components and flavonoids do not show any antibiotic activity in our test. Key Word Index Ruta graveolens - Rutaceae - Antimicrobial substances - Acridone alkaloid epoxides - Furoquinoline alkaloids - Furocoumarins - Rutarin - Callus culture PDF (404 kb)
