Abstract
Chronic administration of cannabis extract (14 mg/kg body wt for 90 days) caused testicular
lesions resulting in mass atrophy of the spermatogenic elements. RNA, protein and
sialic acid contents of the testes and epididy-mides were reduced; whereas the alkaline
phosphatase and cholesterol contents of the testes were elevated. Liver glycogen and
adrenal ascorbic acid contents were low. Degranulation and vacuolization of hepatocytoplasm
was conspicuous which was further reflected in elevated transaminases, bilirubin,
NEFA, phospholipids, free and total cholesterol. Serum protein, alkaline and acid
phosphatase, triglycerides, blood sugar, blood urea and creatinine phosphate levels
were in normal range. Hematological studies did not reveal any deviation from the
normal range except a rise in leucocyte counts.
In conclusion, the severity and consistency of damage caused to the testis and liver
in man by frequent use of marijuana and its derivatives is very alarming.
Key Word Index
Cannabis sativa - Cannabaceae - Testicular Function - Transaminases
