Neuropediatrics 1999; 30(4): 205-209
DOI: 10.1055/s-2007-973491
Short communications

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Spontaneous Improvement of Optic Pathway Lesions in Children with Neurofibromatosis Type 1

L. N. Rossi1 , F. Triulzi2 , C. Parazzini2 , M. M. Maninetti1
  • 1Department of Pediatrics, University of Milan, Milan, Italy
  • 2Department of Neuroradiology, Ospedale San Raffaele, Milan, Italy
Further Information

Publication History

Publication Date:
12 March 2007 (online)

Abstract

Two cases of spontaneous improvement of optic pathway lesions in neurofibromatosis type 1 are reported. At time of diagnosis the children were aged 21 and 32 months respectively; they have been followed by both MRI and clinical evaluation for 5 and 4 years. MRI findings of the first 19 months of follow-up for Case 1 have been described by us before. On MRI serial evaluation, Case 1 showed an almost complete normalization of the size of lesions and a resolution of enhancement, whereas Case 2 showed a slight decrease in the size of lesions and a resolution of enhancement. From the clinical point of view Case 1 showed a normalization of his clinical signs, whereas in Case 2, a visual improvement was only slight, if at all present. In Case 1, the clinical improvement seemed to follow the spontaneous regression of the lesions detected by MRI.

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