Recurrent Episodes of Coma: An Unusual Phenotype of Familial Hemiplegic Migraine with Linkage to Chromosome 1

B. Echenne; A. Ducros; F. Rivier; A. Joutel; V. Humbertclaude; A. Roubertie; M. Azaïs; M. G. Bousser; E. Tournier-Lasserve

doi:10.1055/s-2007-973493

Neuropediatrics 1999; 30(4): 214-217
DOI: 10.1055/s-2007-973493

Short communications

Recurrent Episodes of Coma: An Unusual Phenotype of Familial Hemiplegic Migraine with Linkage to Chromosome 1

B. Echenne¹ , A. Ducros² ^, ³ , F. Rivier¹ , A. Joutel² , V. Humbertclaude¹ , A. Roubertie¹ , M. Azaïs¹ , M. G. Bousser³ , E. Tournier-Lasserve² ^, ⁴

¹Service de Neuropédiatrie, Hôpital Saint Eloi, Montpellier, France
²INSERM U25, Hôpital Necker, Paris, France
³Service de Neurologie, Hôpital Lariboisière, Paris, France
⁴Service de Génétique, Hôpital Lariboisière, Paris, France

Abstract

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Abstract

Over a period of ten years, a boy had several episodes of coma, lasting three to five days. Each episode was preceded by hemiparesis or paresthesias, aphasia, headaches and behavioural changes, with subsequent loss of consciousness. Partial seizures occurred during the first episode. A history of migraine or hemiplegic migraine was found in several members of the family. Linkage to chromosome 1q21-23, where a gene for familial hemiplegic migraine has been mapped, was shown in this family.

Key words

Migraine - Familial hemiplegic migraine - Coma - Epilepsy

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