Horm Metab Res 1996; 28(6): 289-293
DOI: 10.1055/s-2007-979795

© Georg Thieme Verlag Stuttgart · New York

Genetics of Insulin-Dependent Diabetes; Non-Major Histocompatibility Genes

T. R. Merriman, J. A. Todd
  • University of Oxford, Oxford, United Kingdom
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23. April 2007 (online)


Recently, the major advances in understanding the genetics of type 1 diabetes have come using the positional cloning approach, both in mouse and human. Construction of congenic mouse strains and, in human, the exploitation of linkage disequilibrium between very closely linked markers and disease-predisposing loci, is enabling fine mapping of these loci.