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Horm Metab Res 1996; 28(11): 588-591
DOI: 10.1055/s-2007-979858
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© Georg Thieme Verlag Stuttgart · New York

Somatostatin and Octreotide Interfere with Calcium Signalling in Pancreatic β-Cells but not in Normal and Pathological Parathyroid Cells

P. Ridefelt, J. Rydinge, G. Åkerström, P. Hellman, J. Rastad
  • Department of Surgery, University Hospital, Uppsala, Sweden
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Publication History

Publication Date:
23 April 2007 (online)

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Abstract

Somatostatin and its analogue odreotide exert anti-secretory actions in several endocrine tissues. Somatostatin and octreotide (100 nM) promptly and reversibly counteracted glucose stimulated elevations of the concentration of cytoplasmic Ca2+ ([Ca2+]i) in mouse pancreatic β-cells. In contrast both somatostatin and octreotide failed to affed basal or high Ca2+ stimulated [Ca2+]i of normal bovine, and adenomatous or hyperplastic human parathyroid cells. Furthermore, PTH release of these cells was unaltered by 1-1000 nM somatostatin and octreotide. The results indicate that somatostatin and octreotide lack direct actions on parathyroid cells, which contrasts to their effects on calcium signalling in cells from pancreatic islets.

Key words

Parathyroid Glands - Pancreatic β-Cells - Somatostatin - Octreotide - Calcium

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