© Georg Thieme Verlag Stuttgart · New York
Role of the β3-Adrenoceptor in the Control of Leptin Expression
23. April 2007 (online)
The inhibitory effect of β-adrenoceptor agonists on leptin expression in brown and white adipose tissues is now well documented both in vivo and in vitro. It suggests the existence in vivo of a retroregulatory loop by which leptin inhibits its own expression via the sympathetic nervous system and the β3-adrenoceptor. The hypothesis that the defect in β3-adrenoceptor described in the adipose tissue of hereditary obese rodents can contribute to the resistance to leptin and to the increase in leptin expression observed in these animals is discussed.
β-Adrenoceptors - Leptin Expression - Adipoctes - Obesity