Abstract
Some reports have suggested the ameliorative effects of estrogens on clinical symptoms,
such as short memory, in women suffering from senile dementia-Alzheimer's tpye, in
vivo. The action mechanism of estrogen remains to be clarified, but 1) an anti-depressive
effect, 2) improvement of cerebral blood flow, 3) direct stimulation of neuron, 4)
development of gliacyte and 5) suppression of apolipoprotein E have been suggested.
Some mechanisms may be combined, contributing to the beneficial effects on clinical
symptoms.
Key words
Senile Dementia-Alzheimer's Type - Estrogen - Depressive Status - Cerebral Blood Flow
- Neuron - Apolipoprotein E
