Hormone and Metabolic Research, Inhaltsverzeichnis Horm Metab Res 1995; 27(6): 275-278DOI: 10.1055/s-2007-979958 Originals Basic © Georg Thieme Verlag Stuttgart · New YorkEffect of Testosterone Administration, Pre- and Postnatally, on the Immune System of RatsM. M. Konstadoulakis1 , K. N. Syrigos1 , 2 , C. N. Baxevanis3 , E. I. Syrigou1 , M. Papamichail3 , P. Peveretos1 , M. Anapliotou2 , B. C. Golematis1 1Laboratory of Tumour Immunology, 1st Department of Propaedeutic Surgery, Hippokration Hospital, Athens Medical School 2Endocrine Unit, Department of Pathophysiology, Athens Medical School 3Department of Immunology, Hellenic Anticancer Institute, Athens, Greece Artikel empfehlen Abstract als PDF herunterladen(opens in new window) Artikel einzeln kaufen(opens in new window) Abstract This study was undertaken to investigate and compare in vitro and in vivo immune parameters between female and male rats. We analysed the T-cell proliferative responses to syngeneic and allogeneic cellular antigens (syngeneic and allogeneic mixed lymphocyte reaction), as well as the IgG levels in the sera of our study groups. It has also been studied the influence of gonadectomy and the effect of testosterone administration pre- and postnatally on the above parameters. Our findings showed that hormonal manipulations, can alter the differences observed in immune response between female and male rats. In addition, it is demonstrated that pre- and postnatal sexual steroid manipulations could provoke long lasting immunological effects. Key words Immune System - Rats - Gonadectomy - Testosterone Administration - Steroid Hormones PDF (341 kb)
