Gold(I)-Catalyzed Rearrangement of Propargylic Alcohols to α,β-Unsaturated Ketones

Abstract

We have developed a gold(I)-catalyzed rearrangement of propargylic alcohols to α,β-unsaturated ketones. The reaction might proceed through a dehydration of an alkynol, followed by an addition of water to a cumulene intermediate. The substituents of the alkynol play an important role in the rearrangement.

gold - Meyer-Schuster - rearrangement - α,β-unsaturated ketones - propargylic alcohol

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