Zusammenfassung
Forschungsergebnisse zur Wirksamkeit von Cranberry als Prophylaktikum bei rezidivierenden
Harnwegsinfekten werden vorgestellt. Proanthocyanidine der Cranberries hemmen
die bakterielle Andockung an Gewebe in vitro und nach oraler Aufnahme und Ausscheidung
in den Urin bei Probanden. Durch randomisierte klinische Studien ist die Prophylaxe
von Harnwegsinfekten durch Cranberrysaft bei Frauen evidenzbasiert. Die Antiadhäsionswirkung
der Cranberry kann auch in der Therapie und Prophylaxe anderer bakterieller
Erkrankungen wie Helicobacter pylori assoziierter Gastritis oder Karies eingesetzt
werden. Die hohe antioxidative Kapazität von Cranberryprodukten ist zusätzlich
eindrucksvoll belegt.
Abstract
Cranberry (Vaccinium macrocarpon) is a North-American folk remedy for treating
and preventing infection. Research has identified an anti-adhesive mechanism of
cranberry-proanthocyanidins that inhibit docking of bacteria on tissues in vitro.
The efficacy of cranberry juice and extracts as a prophylactic agent against recurrent
urinary infections is well documented in women. The anti-adhesion effect of cranberry-proanthocyandins
can also be applied for treatment of other common diseases of bacterial pathogenesis,
e.g. Helicobacter pylori-associated gastritis and dental caries/parodontal disease.
Cranberries have an exceptionally high anti-oxidative capacity.
Schlüsselwörter
Cranberry - Proanthocyanidine - Harnwegsinfekte - Escherichia coli - Antiadhärenz
- Fimbrien - Helicobacter pylori - Karies - Antioxidanzien
Keywords
Cranberry - proanthocyanidins - urinary tract infection - Escherichia coli - anti-adhesion
- fimbriae - Helicobacter pylori - tooth decay - anti-oxidatives
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