Abstract
Respiratory symptoms, such as tussis, haemoptysis, pleural effusion and dyspnoea,
are common in palliative care patients and tend to increase as the underlying disease
advances. Compared to the other symptoms, dyspnoea is of different nature, insofar
as it is a subjective symptom where only the patient himself is in a position to judge
its severity. It is not self-evident that measurable pathophysiological changes are
to be found. Profound knowledge of physiology and pathophysiology is indispensable
for targeted diagnostics and rational therapy. Key strategies of treatment include
measures that will reduce increased breathing effort and respiratory rate, improve
CO2 elimination and have a positive impact on the distressing and emotional response
to the experience of air hunger.
Literatur
- 1
Gugger M, Bachofen H.
Dyspnoe, Grundlagen und Pathophysiologie.
Schweiz Med Forum.
2001;
Nr. 6
- 2 Pfreundschuh M, Schölmerich J. Pathophysiologie/Pathobiochemie. München; Urban &
Fischer 2000: 187-206
- 3 Thews G.
Lungenatmung. In: Schmidt RF, Thews G (Hrsg) Physiologie des Menschen. 24. Aufl. Berlin; Springer
1990: 574-609
- 4 Thews G.
Lungenatmung. In: Schmidt RF, Thews G (Hrsg) Physiologie des Menschen. 27. Aufl. Berlin; Springer
1997: 565-603
- 5
Moosavi S H, Golestanian E, Binks A P. et al .
Hypoxic and hypercapnic drives to breathe generate equivalent levels of air hunger
in humans.
J Appl Physiol.
2003;
94
141-154
- 6 Thews G.
Lungenatmung. In: Schmidt RF, Thews G (Hrsg) Physiologie des Menschen. 17. Aufl. Berlin; Springer
1976: 452-486
- 7 Zander R. Sauerstoff von A-Z: Von der Alveole bis zur Zelle. Refresher Course. Aktuelles
Wissen für Anästhesisten. Herausgegeben von der Deutschen Akademie für Anästhesiologische
Fortbildung, Nürnberg. Juni 2002 Nr. 28
- 8 Clemens K E, Klaschik E.
Respiratorische Symptome. In: Aulbert E, Nauck F, Radbruch L (Hrsg) Lehrbuch der Palliativmedizin. 2. Aufl. Stuttgart;
Schattauer 2007: 375-393
- 9
Manning H L, Schratzenstein R M.
Pathophysiology of Dyspnea. Review.
N Engl J Med.
1995;
333
1547-1553
- 10
Bruera E, Sweeney K, Willey J. et al .
A randomized controlled trial of supplemental oxygen versus air in cancer patients
with dyspnea.
Palliat Med.
2003;
17
659-663
- 11
Ventafridda V.
Palliative Care: A new reality in medicine.
Rec Res Cancer Res.
1991;
121
393-398
- 12
Bausewein C, Farquhar M, Booth S. et al .
Measurement of breathlessness in advanced disease: a systematic review.
Respir Med.
2007;
101
399-410
- 13 Klaschik E.
Schmerztherapie und Symptomkontrolle in der Palliativmedizin. In: Husebö S, Klaschik E (Hrsg) Palliativmedizin. 4. Aufl. Berlin; Springer 2006:
276-279
- 14
Bourke D L, Warley A.
The steady state and breathing methods compared during morphine administration in
humans.
J Physiol.
1989;
419
509-517
- 15
Clemens K E, Klaschik E.
Symptomatic therapy of dyspnea with strong opioids and its effect on ventilation in
palliative care patients.
J Pain Symptom Manage.
2007;
33 (4)
473-481
- 16
Bouillon T, Bruhn J, Roepcke H. et al .
Opioid-induced respiratory depression is associated with increased tidal volume variability.
Eur J Anaesthesiol.
2003;
20 (2)
127-133
- 17
Argyropoulou P, Patakas D, Koukou A. et al .
Buspirone effect on breathlessness and exercise performance in patients with chronic
obstructive pulmonary disease.
Respiration.
1993;
60 (4)
216-220
- 18 Ahmedzai S.
Palliation of respiratory symptoms. In: Doyle D, Hanks GWC, MacDonald N (eds) Oxford Textbook of Palliative Medicine.
2nd. ed. Oxford; Oxford Univ Press 1998: 583-616
- 19 Doyle D. Domicially terminal care. Edinburgh; Churchill Livingstone 1987: 33-34
- 20
Green K, Webster H, Watanabe S. et al .
Management of nosocomial respiratory tract infections in terminally ill cancer patients.
J Palliat Care.
1994;
10 (4)
31-34
- 21
Oneschuk D, Faisinger R, Demoissac D.
Antibiotic use in the last week of life in three different palliative care settings.
J Palliat Care.
2002;
18 (1)
25-28
- 22
Pereira J, Watanabe S, Wolch G.
A retrospective review of the frequency of infections and patterns of antibiotic utilization
on a palliative care unit.
J Pain Symptom Manage.
1998;
16 (6)
374-381
- 23
Vietta L, Kenner D. et al .
A bacterial infection in terminally ill hospice patients.
J Pain Symptom Manage.
2000;
20 (5)
326-334
- 24
Sorbye L W.
A longitudinal study on dying in a Norwegian hospital.
Int J Palliat Nurs.
2000;
6 (2)
71-79
- 25
Evers M M, Purohit D, Perl D. et al .
Palliative and aggressive end-of-life care for patients with dementia.
Psychiatr Serv.
2002;
53 (5)
609-613
- 26
Philip J, Gold M, Milner A. et al .
A randomized, double-blind, crossover trial of the effect of oxygen on dyspnoea in
patients with advanced cancer.
J Pain Symptom Manage.
2006;
32 (6)
541-550
- 27
Higginson I J, McCarthy M.
Measuring symptoms in terminal cancer: are pain and dyspnoea controlled?.
J Royal Soc Med.
1989;
82
264-267
- 28 Wilcock A.
The management of respiratory Symptoms. In: Faull C, Carter Y, Woof R (eds) Handbook of Palliative Care. Oxford; Blackwell
1998 Chapter 11: 157-176
- 29 Driver L C, Bruera E.
Dyspnea. In: Driver LC, Bruera E The M.D. Anderson Palliative Care Handbook. 2nd. ed. Houston,
TX; University of Texas, M.D. Anderson Cancer Centre 2002: 71-76
Dr. med. Katri Elina Clemens
Lehr- und Forschungsstelle Universität Bonn, Zentrum für Palliativmedizin, Malteser
Krankenhaus Bonn/Rhein-Sieg
Von-Hompesch-Straße 1
53123 Bonn
eMail: katri-elina.clemens@malteser.de