Exp Clin Endocrinol Diabetes 2008; 116(2): 118-122
DOI: 10.1055/s-2007-990296
Article

© J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart · New York

Age-specific Characteristics of the Basal Insulin-rate for Pediatric Patients on CSII

C. Klinkert 1 , R. Bachran 2 , B. Heidtmann 4 , M. Grabert 3 , R. W. Holl 3 , For the DPV-Initiative
  • 1Pediatric Practice, Herford, Germany
  • 2Pediatric Practice, Oberhausen, Germany
  • 3Department of Epidemiology, University of Ulm, Germany
  • 4Cath. Childrens Hospital Wilhelmstift, Hamburg, Germany
Further Information

Publication History

received 18.06.2007 first decision 30.07.2007

accepted 30.07.2007

Publication Date:
31 October 2007 (online)

Abstract

Objective: This study intends to analyse the basal insulin dosage for pediatric patients (0-18 years) with type 1 diabetes on insulin-pump therapy (CSII).

Research design and methods: In a large German and Austrian prospectively documented data base (DPV) for children with diabetes, patients with CSII were identified. The documented basal rates from patients (0-18 years) were analysed and related to age, gender, duration of diabetes, body weight and type of insulin used in the pump. Data were evaluated for three age groups (0-6; >6-12; >12-18 years).

Results: Complete data sets with documented hourly intervals of basal rate were available from 743 patients. Basal insulin dosage in the 3 age groups differed significantly (0-6 years 0.20 IU/kg body weight; >6-12 years 0.34 IU/kg body weight; >12-18 years 0.41 IU/kg body weight p<0.0001). The amount of basal insulin in 24 hours in each group correlates with body weight, age and duration of diabetes. The circadian distribution of the basal rate shows different profiles in each age group.

Conclusion: Pediatric patients on CSII have age specific characteristics in total amount and circadian distribution of basal rates.

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Correspondence

C. KlinkertMD 

Alter Markt 9

32052 Herford

Germany

Phone: +49/5221/51 99 3

Fax: +49/5221/51 15 1

Email: dr.klinkert@t-online.de

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