Solvent-Free Synthesis of Urea Derivatives from Primary Amines and Sulfur under Carbon Monoxide and Oxygen at Atmospheric Pressure

Takumi Mizuno; Masatoshi Mihara; Takeo Nakai; Toshiyuki Iwai; Takatoshi Ito

doi:10.1055/s-2007-990793

PAPER

Solvent-Free Synthesis of Urea Derivatives from Primary Amines and Sulfur under Carbon Monoxide and Oxygen at Atmospheric Pressure

Takumi Mizuno*, Masatoshi Mihara, Takeo Nakai, Toshiyuki Iwai, Takatoshi Ito
Osaka Municipal Technical Research Institute, 1-6-50, Morinomiya, Joto-ku, Osaka 536-8553, Japan
Fax: +81(6)69638049; e-Mail: tmizuno@omtri.city.osaka.jp;

Abstract

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Abstract

A solvent-free carbonylation and oxidation system aimed at green and sustainable chemistry was developed. With these reactions, an environmentally benign synthesis of urea derivatives could be carried out in good to excellent yields from primary amines and sulfur at ambient pressure of carbon monoxide and oxygen. For example, N,N′-dioctylurea was prepared in 99% yield from two equivalents octylamine and one equivalent sulfur in the presence of carbon monoxide (1 atm) at 80 °C and oxygen (1 atm) at room temperature, in the complete absence of solvent.

Key words

urea derivatives - carbon monoxide - oxygen - sulfur - solvent-free

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Referenzen

References

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