A Convenient, High-Yielding Copper-Free Synthesis of Skipped 1,4-Diynes

Abstract

Alkynylalanes were found to react efficiently with propargylic electrophiles, such as propargyl mesylates and propargyl diethylphosphates. The reaction proceeds with high regioselectivity and does not require copper or any other transition metal.

alkynes - alanes - aluminum - cross-coupling - regioselectivity

References

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