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Synthesis of (+)-Fomannosin
L. A. Paquette*, X. Peng, J. Yang
The Ohio State University, Columbus, USA
23 January 2008 (online)
(+)-Fomannosin is a phythopathogenic metabolite isolated from the wood-rotting fungus Fomes annosus (Fr.) Karst. A zirconocene-mediated ring contraction (AÆB) is the key step of the present synthesis. The d-glucose-derived tetrahydrofuran A was transformed into the natural product in 23 steps.