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Synfacts 2008(2): 0218-0218  
DOI: 10.1055/s-2007-992511
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Three-Component Coupling Reaction Using Silica-Immobilized CuI Catalyst

Contributor(s): Yasuhiro Uozumi, Hiroe Takenaka
P. R. Likhar*, S. Roy, M. Roy, M. S. Subhas, M. L. Kantam, R. L. De
Indian Institute of Chemical Technology, Hyderabad and Jadavpur University, Kolkata, India
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Publikationsdatum:
23. Januar 2008 (online)

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Signifance

The three-component coupling of aldehydes, amines, and alkynes by using silica-immobilized CuI catalyst was described. Silica-supported copper catalyst SiO 2 -Py-CuI was prepared from 2-pyridylimine functionalized silica SiO 2 -Py with CuI in acetonitrile (eq. 1). The three-component coupling reactions of aldehydes, amines, and alkynes were carried out in the presence of 5 mol% silica-immobilized CuI catalyst SiO 2 -Py-CuI in ­acetonitrile at 90 °C to give the corresponding propargylamines in 54-93% yield (eq. 2).