Horm Metab Res 1980; 12(7): 323-327
DOI: 10.1055/s-2007-996280

© Georg Thieme Verlag, Stuttgart · New York

Comparative Metabolic and Cardiovascular Effects of Carbuterol, Isoproterenol, Metaproterenol and Salbutamol in the Baboon

D. E. Potter, L. C. Woodson, R. R. Kempen, S. Ellis
  • Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, U.S.A.
Further Information

Publication History



Publication Date:
14 March 2008 (online)


The metabolic and cardiovascular responses to two bronchiolar selective β-adrenergic drugs, carbuterol (CAR) and salbutamol (SAL), were compared with isoproterenol (ISO) and metaproterenol (MET) in fasted, anesthetized baboons. ISO was more active than the selective β-adrenergic drugs in elevating plasma levels of glucose, lactate, free fatty acids, insulin, and glucagon. Moreover, ISO was more active in increasing heart rate and respiratory rate and in depressing diastolic blood pressure. Although ISO was shown to have greater activity than CAR, MET, and SAL, the bronchiolar selective drugs (CAR and SAL) did produce significant changes in plasma levels of metabolic substrates and pancreatic hormones and in cardiovascular measurements at higher dose rates.