Alpha-Thalassemia: Prenatal Diagnosis and Neonatal Implications

Mark C. Maberry; Victor R. Klein; Corinne Boehm; Tina C. Warren; Larry C. Gilstrap

doi:10.1055/s-2007-999522

American Journal of Perinatology, Table of Contents

Am J Perinatol 1990; 7(4): 356-358
DOI: 10.1055/s-2007-999522

ORIGINAL ARTICLE

Alpha-Thalassemia: Prenatal Diagnosis and Neonatal Implications

Mark C. Maberry, Victor R. Klein, Corinne Boehm, Tina C. Warren, Larry C. Gilstrap III

Departments of Obstetrics & Gynecology and Pediatrics, University of Texas Southwestern Medical School, Dallas, Texas, and Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, Maryland

Abstract

ABSTRACT

Homozygous α-thalassemia major, or Bart's hemoglobinopathy, is the most common etiology of nonimmune hydrops in those of Oriental descent. The prenatal diagnosis can now be made utilizing DNA hybridization technique from fetal cells obtained by either amniocentesis or chorionic villus sampling. A case is reviewed documenting the utilization of DNA studies in managing patients known or suspected to have a history of α-thalassemia major.

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