Dopamine and Catecholamines in Cystic Fibrosis in Response to a Marathon Race

H. Kollberg; M. Schöni; K. Türler; H. Käser; A. Bardón; O. Ceder; J. K. Stanghelle; S. Mæhlum; D. Skyberg

doi:10.1055/s-2008-1025616

International Journal of Sports Medicine, Table of Contents

Int J Sports Med 1988; 09: S56-S59
DOI: 10.1055/s-2008-1025616

Dopamine and Catecholamines in Cystic Fibrosis in Response to a Marathon Race

H. Kollberg¹ , M. Schöni² , K. Türler³ , H. Käser³ , A. Bardón³ , O. Ceder¹ , J. K. Stanghelle⁴ , S. Mæhlum⁴ , D. Skyberg⁵

¹Department of Pediatrics, University of Umeå, Umeå, Sweden
²Faculty of Pharmaceutical Sciences, Division of Pharmacology, University of British Columbia, Vancouver, Canada
³Institute for Clinical and Experimental Cancer Research, University of Berne, Switzerland
⁴Sunnaas Hospital, Oslo, Norway
⁵Department of Pediatrics, Central Hospital, Aust-Agder, Arendal, Norway

Abstract

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Abstract

The excretions of 3,4-dihydroxyphenylalanine (DOPA) metabolites and 5-hydroxyindoleacetic acid (5-HIAA) were followed before, during, and after a marathon race in three patients with cystic fibrosis (CF) and three healthy controls. Moderately increased DOPA excretions in CFs compared with controls before, during, and after the race support the idea that there is an altered metabolism of DOPA in CF. Noradrenaline, adrenaline, homovanillic acid, and vanilmandelic acid were increased in CFs compared with controls mainly during and after the race, which might be a reflection of the heavier working intensity that the CF patients had in comparison with their healthy controls. 5-HIAA, the breakdown product of serotonin, was higher in CFs in comparison with controls before and during the run, but equal thereafter. This reflects an ameliorated serotonin metabolism after the run.

Key words

catecholamines - cystic fibrosis - DOPA - dopamine - exercise - 5-HIAA - marathon - urine

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