Zusammenfassung
Die Verwendung von Silikonöl Polydimethylsiloxan (PDMS) als Endotamponade ist zu einem
Goldstandard in der Netzhautchirurgie geworden. Ein Nachteil dieser Endotamponade
bei Netzhautablösung ist die häufig nicht ausreichende Tamponadewirkung in der unteren
Zirkumferenz oder im posterioren Anteil des Auges, insbesondere wenn bereits proliferative
Veränderungen vorliegen. Die Verwendung von schweren Ölen könnte bei diesen Formen
von Vorteil sein. Über die klinische Erfahrung mit Densiron® 68, einem Gemisch von
PDMS mit Perfluorhexyloktan (F6 H8), liegen inzwischen erste klinische monozentrische
Beobachtungen vor, über die berichtet wird. Da auch die Verwendung der schweren Flüssigkeit
F 6 H8 allein als Endotamponade zugelassen ist und bei dieser Tamponade von Komplikationen
wie Emulgation und entzündlichen Reaktionen berichtet wurde, werden zusätzlich auch
die hierzu vorliegenden Untersuchungen und Bewertungen dargestellt. Schwere Silikonölendotamponaden
haben den Vorteil einer kürzeren Tamponadezeit und einfacherer Lagerung für den Patienten.
Weitere Forschungen zur Entwicklungen von schweren Ölen mit geringerer Neigung zur
Emulgation laufen derzeit.
Abstract
The use of polydimethylsiloxane (PDMS) as silicone oil endotamponade has become a
gold standard in retinal surgery. In cases of complicated retinal detachment with
inferior and posterior retinal detachment this tamponade may be insufficient, and
heavy silicone oils may be superior in such cases. Monocentric studies about use of
the heavy silicone oil Densiron® 68, a mixture of PDMS with perfluorohexyloctane (F6
H8), are reviewed. Meanwhile, F 6 H8 is approved as sole endotamponade, but complications
such as emulsification and inflammation associated with the use of only F 6 H8 as
endotamponade are reported and will also be reviewed. An advantage of heavy silicone
oils is the relatively short residence time of the endotamponade. An uncomfortable
“head down” position of the patients after surgery is not necessary. Current research
focusses on developing new heavy silicone oils with a lower tendency to emulsify.
Schlüsselwörter
Densiron 68 - Perfluorkarbon - schweres Silikonöl - komplizierte Amotio retinae -
Netzhautablösung - Endotamponade
Key words
Densiron 68 - perfluorocarbon liquids - heavy silicone oil - complicated retinal detachment
- endotamponade agents
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PD Katrin Engelmann
Augenklinik, Klinikum Chemnitz gGmbH
Flemmingstr. 2
09116 Chemnitz
Telefon: ++ 49/3 71/33 33 32 30
Fax: ++ 49/3 71 + 33 33 32 23
eMail: k.engelmann@skc.de
