Extract of Pelargonium sidoides (EPs® 7630) Displays Anti-Infective Properties by Enhanced Phagocytosis and Differential Modulation of Host-Bacteria Interactions

Abstract

EPs® 7630 is an aqueous-ethanolic extract of the roots of Pelargonium sidoides that displays well-documented benefits in the treatment of upper respiratory tract infections (URTI). In vitro and animal investigations have revealed various anti-infective properties of EPs® 7630. The present review sums up recently published in vitro investigations that have shown positive effects on the activity of human peripheral blood phagocytes (PBP) and differential modulation of the interactions between group A streptococci and the host’s epithelial barrier.

Pelargonium sidoides DC - EPs® 7630 - Geraniaceae - upper respiratory tract infection (URTI) - phagocytosis - group A streptococci - adhesion

References

• 1 Bladt S, Wagner H. From the Zulu medicine to the European phytomedicine Umckaloabo®.  Phytomedicine. 2007;  14 2-4
• 2 Chuchalin A G, Berman B, Lehmacher W. Treatment of acute bronchitis in adults with a Pelargonium sidoides preparation (EPs® 7630): A randomized, double-blind, placebo-controlled trial.  Explore. 2005;  1 437-45
• 3 Matthys H, Heger M. Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs® 7630): a randomised, double-blind, placebo-controlled, multi-centre study.  Curr Med Res Opin. 2007;  23 323-31
• 4 Bereznoy V V, Riley D S, Wassmer G, Heger M. Efficiacy of extract of Pelargonium sidoides in children with acute non-group A beta-hemolytic streptococcus tonsillopharyngitis: a randomized, double-blind, placebo-controlled trial.  Altern Ther Health Med. 2003;  9 8-78
• 5 Kolodziej H, Kayser O, Radtke O A, Kiderlen A F, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents.  Phytomedicine. 2003;  10 8-24
• 6 Trun W, Kiderlen A F, Kolodziej H. Nitric oxide synthase and cytokines gene expression analyses in Leishmania-infected RAW 264.7 cells treated with an extract of Pelargonium sidoides (EPs® 7630).  Phytomedicine. 2006;  13 570-5
• 7 Kayser O, Kolodziej H, Kiderlen A F. Immunomodulatory principles of Pelargonium sidoides. .  Phytother Res. 2001;  15 122-6
• 8 Kolodziej H, Kayser O, Kiderlen A F, Ito H, Hatano T, Yoshida T. et al . Proanthocyanidins and related compounds: antileishmanial activity and modulatory effects on nitric oxide and tumor necrosis factor-α-release in the murine macrophage-like cell line RAW 264.7.  Biol Pharm Bull. 2001;  24 1016-21
• 9 Kolodziej H, Burmeister A, Trun W, Radtke O A, Kiderlen A F, Ito H. et al . Tannins and related compounds induce nitric oxide synthase and cytokines gene expression in Leishmania major-infected macrophage-like RAW 264.7 cells.  Bioorg Med Chem. 2005;  13 6470-6
• 10 Radtke O A, Kiderlen A F, Kayser O, Kolodziej H. Gene expression profiles of inducible nitric oxide synthase and cytokines in Leishmania major-infected macrophage-like RAW 264.7 cells treated with gallic acid.  Planta Med. 2005;  70 924-8
• 11 Conrad A, Hansmann C, Engels I, Daschner F D, Frank U. Extract of Pelargonium sidoides (EPs® 7630) improves phagocytosis, oxidative burst, and intracellular killing of human peripheral blood phagocytes in vitro. .  Phytomedicine. 2007;  14 46-51
• 12 Nöldner M, Schötz K. Inhibition of lipopolysaccharid-induced sickness behavior by a dry extract from the roots of Pelargonium sidoides (EPs® 7630) in Mice.  Phytomedicine. 2007;  14 27-31
• 13 Schötz K, Nöldner M. Mass spectroscopic characterization of oligomeric proanthocyanidins derived from an extract of Pelargonium sidoides roots (EPs® 7630) and pharmacological screening in CNS models.  Phytomedicine. 2007;  14 32-9
• 14 Conrad A, Jung I, Tioua D, Lallemand C, Carrapatoso F, Engels I. et al . Extract of Pelargonium sidoides (EPs® 7630) inhibits the interactions of group A streptococci and host epithelia in vitro. .  Phytomedicine. 2007;  14 52-9
• 15 Beil W, Klilian P. EPs® 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells.  Phytomedicine. 2007;  14 5-8
• 16 Wittschier N, Faller G, Hensel A. An extract of Pelargonium sidoides (EPs® 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach.  Phytomedicine. 2007;  14 285-8
• 17 Neugebauer P, Mickenhagen A, Siefer O, Walger M. A new approach to pharmacological effects on ciliary beat frequency in cell cultures - exemplary measurements under Pelargonium sidoides extract.  Phytomedicine. 2005;  12 47-52
• 18 Henneke P, Golenbock D T. Phagocytosis, innate immunity, and host-pathogen specifity.  J Exp Med. 2004;  199 -4
• 19 Salih H R, Husfeld L, Adam D. Simultaneous cytofluorometric measurement of phagocytosis, burst production and killing of human phagocytes using Candida albicans and Staphylococcus aureus as target organisms.  Clin Microbiol Infect. 2000;  6 51-8
• 20 Greenberg S, Grinstein S. Phagocytosis and innate immunity.  Curr Opin Immunol. 2002;  14 36-45
• 21 Courtney H S, Hasty D L, Dale J B. Molecular mechanisms of adhesion, colonization, and invasion of group A streptococci.  Ann Med. 2002;  34 7-87
• 22 LaPenta D, Rubens C, Chi E, Cleary P. Group A streptococci efficiently invade human respiratory epithelial cells.  Proc Natl Acad Sci U S A. 1994;  91 12 115-9
• 23 Österlund A, Popa R, Nikkila T, Scheynius A, Engstrand L. Intracellular reservoir of Streptococcus pyogenes in vivo: a possible explanation for recurrent pharyngotonsillitis.  Laryngoscope. 1997;  107 40-6
• 24 Niederman M. Bacterial adherence as a mechanism of airway colonization.  Eur J Clin Microbiol Infect Dis. 1989;  8 5-20
• 25 Sethman C R, Doyle R J, Cowan M M. Flow cytometric evaluation of adhesion of Streptococcus pyogenes to epithelial cells.  J Microbiol Methods. 2002;  51 35-42