Thorac Cardiovasc Surg 2009; 57: S170-S171
DOI: 10.1055/s-2008-1039258
DHZB Symposia

© Georg Thieme Verlag KG Stuttgart · New York

Correlation of Transplant Vasculopathy with Long-Term Survival

E. Wellnhofer1 , M. Dandel1 , N. E. Hiemann1 , H. B. Lehmkuhl1 , C. Knosalla1 , R. Hetzer1
  • 1Deutsches Herzzentrum Berlin (DHZB), Berlin, Germany
Further Information

Publication History

Publication Date:
30 April 2009 (online)

Introduction

Survival after heart transplantation (HTx) has improved, largely due to improvements in early survival. The current half-life time after HTx is now about 10 years [1], [2], [3]. In agreement with data from the ISHLT registry but in contrast to data from Oeynhausen [3], the DHZB experience demonstrates significantly improved survival in patients transplanted between 1992 and 2001 [2]. In contrast to registry data, survival after HTx after 2001 at the DHZB is not improved in comparison with the preceding period ([Fig. 1]).

Fig. 1 Survival after HTx at DHZB conditional on 1-month survival stratified with respect to time period of HTx.

Fig. 2 Survival conditional on 5-year survival, no children, HTx later than 1991.

References

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  • 2 Taylor D O, Edwards L B, Boucek M M, Trulock E P, Aurora P, Christie J. et al . Registry of the International Society for Heart and Lung Transplantation: twenty-fourth official adult heart transplant report – 2007.  J Heart Lung Transplant. 2007;  26 769-781
  • 3 Tjang Y S, van der Heijden G J, Tenderich G, Grobbee D E, Korfer R. Survival analysis in heart transplantation: results from an analysis of 1290 cases in a single center.  Eur J Cardiothorac Surg. 2008;  33 856-861
  • 4 Wellnhofer E, Hiemann N E, Hug J, Dreysse S, Knosalla C, Graf K. et al . A decade of percutaneous coronary interventions in cardiac transplant recipients: a monocentric study in 160 patients.  J Heart Lung Transplant. 2008;  27 17-25
  • 5 Eisen H J, Tuzcu E M, Dorent R, Kobashigawa J, Mancini D, Valantine-von Kaeppler H A. et al . Everolimus for the prevention of allograft rejection and vasculopathy in cardiac-transplant recipients.  N Engl J Med. 2003;  349 847-858
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  • 7 Kobashigawa J A, Tobis J M, Mentzer R M, Valantine H A, Bourge R C, Mehra M R. et al . Mycophenolate mofetil reduces intimal thickness by intravascular ultrasound after heart transplant: reanalysis of the multicenter trial.  Am J Transplant. 2006;  6 (5 Pt 1) 993-997

Dr. med. Ernst Wellnhofer

DHZB

Augustenburger Platz 1

13353 Berlin

Germany

Phone: + 49 (0) 30 45 93 24 98

Fax: + 49 (0) 30 45 93 25 00

Email: wellnhofer@dhzb.de

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