Etiology and Pathogenesis of Multiple Sclerosis

Torben L. Sørensen; Richard M. Ransohoff

doi:10.1055/s-2008-1040879

Seminars in Neurology, Table of Contents

Semin Neurol 1998; 18(3): 287-294
DOI: 10.1055/s-2008-1040879

Etiology and Pathogenesis of Multiple Sclerosis

Torben L. Sørensen¹ ^, ² , Richard M. Ransohoff¹

¹Department of Neurosciences, The Lerner Research Institute and Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic Foundation, Cleveland, Ohio
²Department of Neurology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark

Abstract

ABSTRACT

The cause of multiple sclerosis (MS) remains unknown despite decades of intense research. The major research disciplines that have been brought to bear on this question include genetics, epidemiology, neuropathology, immunology, and virology. Recent advances in the understanding of the inflammatory characteristics of the MS lesion may herald the development of specific and effective treatments. The goal of this research is to improve our management of a disease that remains the major cause of neurologic disability among young adults in North America and Europe.

Keywords

Multiple sclerosis - pathogenesis

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