Diastereoselective Cascade Reactions: Cyclization-Cross-Coupling

V. B. Phapale; E. Buñuel; M. García-Iglesias; D. J. Cárdenas

doi:10.1055/s-2008-1042700

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Synfacts 2008(3): 0280-0280
DOI: 10.1055/s-2008-1042700

Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions

Diastereoselective Cascade Reactions: Cyclization-Cross-Coupling

Contributor(s): Mark Lautens, Valentina Aureggi
V. B. Phapale, E. Buñuel, M. García-Iglesias, D. J. Cárdenas*
Universidad Autonoma de Madrid, Spain

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Publikationsdatum:
21. Februar 2008 (online)

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Significance

Metal-catalyzed C(sp³)-C(sp³) cross-coupling reactions represent an important process in modern organic chemistry. An efficient nickel-catalyzed cross-coupling reaction of alkyl iodides with alkyl zinc bromides is reported. The synthesis of more complex molecules is achieved in moderate to good yields with excellent diastereoselectivities.