ortho-Selective Cross-Coupling of Dichlorobenzenes with Grignard Reagents

Significance

The problem of the regioselectivity in cross-coupling reactions of functionalized di­haloarenes is important from the practical point of view. In this publication, the authors demonstrated highly ortho-selective coupling reactions of dichlorinated phenols, anilines and their derivatives, bearing an anionic coordinating group. Aryl, hetaryl, and alkenylmagnesium halides are suitable coupling partners. Using a specially designed ligand 1, o-chlorine can be coupled preferentially in the presence of a bromine atom in another position.