Simple and Universal Pd(II) Precatalyst for the Suzuki-Miyaura Cross-Couplings

Significance

Catalytic C-C bond-forming processes are among the most important reactions in the contemporary organic synthesis. Herein, the authors demonstrated the feasibility and high activity of the readily available, commercial compound PdBr(N-Succ)(PPh₃)₂ (1) in a number of Suzuki-Miyaura cross-coupling reactions. Aryl and benzylic halides as well as 2-iodoenones in the presence of this catalyst can be readily coupled with aryl-, hetaryl- and alkenylboronic acids, including those prone to protodeborylation. The catalyst can be efficiently recycled, using a polyethylene oxide additive.