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N,N′-Dioxide-Sc(III) Catalyst for Enantioselective Aza-Diels-Alder Reaction
D. Shang, J. Xin, Y. Liu, X. Zhou, X. Liu, X. Feng*
Sichuan University, Chengdu, P. R. of China
19 March 2008 (online)
The development of a new chiral l-proline-derived N,N′-dioxide-scandium(III) catalyst for an efficient enantioselective aza-Diels-Alder reaction is reported. The corresponding 2,5-disubstituted dihydropyridinone products, from aldimines and a Danishefsky-type diene, are obtained with up to 92% yield and 92% ee.