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Biocatalytic Reduction of Aryl Imines
T. Vaijayanthi, A. Chadha*
Indian Institute of Technology Madras, Chennai, India
19 March 2008 (online)
The authors developed a one-pot biocatalytic method for the asymmetric reduction of aryl imines 1. Whole cells of Candida parapsilosis ATCC 7330 (2) generate the corresponding secondary amines 3 without the need for adding a cofactor in aqueous medium. Excellent enantiomeric ratios (er = 97.5:2.5 up to >99.5:0.5) and good yields (55-80%) are reported.