Synfacts 2008(4): 0357-0357  
DOI: 10.1055/s-2008-1042864
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

A Palladium-Catalyzed Carbonylative Cross-Coupling Route to Imidazolones

Contributor(s): Victor Snieckus, Johnathan Board
A. R. Siamaki, D. A. Black, B. A. Arndtsen*
McGill University, Montreal, Canada
Further Information

Publication History

Publication Date:
19 March 2008 (online)


Reported is the one-pot synthesis of diaryl- and triaryl-substituted imidazolones by reaction of readily available chloroformates, imines, carbon monoxide, and stannanes under Pd-catalyzed conditions. The procedure was developed incrementally and a catalytic cycle for the carbonylative cross-coupling is proposed. Although the reaction technically has two steps, these both occur in the same reaction vessel.