A Suspected Case of Late-Onset Sodium-Valproate-lnduced Hepatic Failure
16 May 2008 (online)
A 15-year-old boy was under anti-epileptic medication (diphenylhydantoine, phenobarbital and Na valproate) for more than five years. He was admitted in cerebral coma and died after 24 hours. The histological findings suggest a valproate induced liver toxicity. This long interval between start of treatment and a possibly related hepatic failure has not been described.
Antiepileptic drugs - Sodium valproate - Chronic intoxication - Late onset