Neuropediatrics 1983; 14(3): 149-154
DOI: 10.1055/s-2008-1059568
© Georg Thieme Verlag KG Stuttgart · New York

Cranial Computed Tomography of 64 Children in Continuous Complete Remission of Leukemia II: Relations to Patient Data and Neurological Complications

U.  Stephani1 , G.  Harten1 , H. -J. Langermann1 , H.  Riehm1 , F.  Hanefeld1 , E.  Habermalz2 , H.-J.  Habermalz2
  • 1Kinderklinik des Klinikums Charlottenburg, Freie Universität Berlin, Heubnerweg 6, 1000 Berlin 19, Federal Republic of Germany
  • 2Radiologische Klinik des Klinikums Charlottenburg, Freie Universität Berlin, Spandauer Damm 130, 1000 Berlin 19, Federal Republic of Germany
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Publication History

Publication Date:
19 March 2008 (online)

Abstract

Abnormal widening of cortical sulci as seen in posttherapeutic cranial computed tomography (CCT) of 64 children in complete continuous remission (CCR) of acute lymphoblastic leucemia (ALL)/non Hodgkin's lymphoma (NHL) was related to patient data and neurological complications during the application of West Berlin treatment protocol. Age and neurological/neurodevelopmental findings of the patients at diagnosis of their disease positively and significantly correlated with CCT abnormalities. Abnormal pre- and intratherapeutic electroencephalographic (EEG) recordings, the development of a severe polyneuropathy syndrome and/or a considerable loss of weight during treatment were frequently associated with an abnormal widening of cortical sulci. Occurrence of transient early encephalopathy syndrome, development of radiation induced blood brain barrier disturbance and somnolence syndrome were not correlated with these CCT changes. Possible explanations of these abnormalities are discussed.

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