Subscribe to RSS
DOI: 10.1055/s-2008-1059588
© Georg Thieme Verlag KG Stuttgart · New York
Response of Kidney and Bone to Parathyroid Hormone in Children Receiving Anticonvulsant Drugs
Publication History
Publication Date:
19 March 2008 (online)

Abstract
The response of kidney and bone to parathyroid extract (PTE) was investigated in 8 epileptic children on long-term treatment with primidone in combination with phenytoin or other anticonvulsant drugs. The results indicate a dissociation between normal cyclic AMP excretion and disturbed renal handling of phosphate which resembles type II pseudohypoparathyroidism suggesting an anticonvulsant drug related inhibition of cyclic AMP-induced phosphaturia. It is speculated that antiepileptic drugs may provoke renal conservation of phosphate which may explain the relative low incidence of manifest rickets or osteomalacia in spite of low 25-hydroxyvitamin D levels in epileptic patients.
A normal bone response to PTE indicates that antiepileptic treatment with phenobarbital and phenytoin does not affect PTH-stimulated bone resorption in the investigated patients.
Key words
Anticonvulsant bone disease - Urinary cyclic AMP - Urinary hydroxyproline - Pseudohypoparathyroidism