Synthesis of Selenophene Analogues of the Tacrine Series: Comparison of Classical Route and Microwave Irradiation

David Thomae; Gilbert Kirsch; Pierre Seck

doi:10.1055/s-2008-1067001

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Synthesis 2008(10): 1600-1606
DOI: 10.1055/s-2008-1067001

PAPER

Synthesis of Selenophene Analogues of the Tacrine Series: Comparison of Classical Route and Microwave Irradiation

David Thomae^a, Gilbert Kirsch*^a, Pierre Seck^b
^a Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol, FR CNRS 2843, 1 Boulevard Arago, 57070 Metz, France
Fax: +33(3)87315801; e-Mail: kirsch@univ-metz.fr;
^b Laboratoire de Chimie, Faculté des Sciences, de la Technologie et de la Communication, Université du Luxembourg, 162a Avenue de la Faïencerie, 1511 Luxembourg, Grand-Duché de Luxembourg

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Publication History

Received 28 January 2008
Publication Date:
27 March 2008 (online)

Abstract
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Abstract

New 3-amino-2-selenophenecarbonitriles condensed with cyclanones to afford, in one step, analogues of Tacrine. A comparison between classical heating and microwave irradiation for the Friedländer condensation is presented.

Key words

Alzheimer disease - Tacrine analogues - Friedländer reaction - 3-amino-2-cyanoselenophenes - sodium selenide - microwave irradiation

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